Tadapox 80mg is a combination medication that includes Tadalafil and Dapoxetine. Tadalafil can last up to 36 hours in your system, providing a prolonged window of effectiveness for erectile dysfunction. Dapoxetine, on the other hand, is usually effective for about 4 to 6 hours, as it's primarily used to treat premature ejaculation.

However, the duration can vary depending on individual factors like metabolism, age, and overall health. It's always best to follow your healthcare provider's guidance on how to use this medication and discuss any concerns about its duration or effects.